Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study

Background: Hippocampal atrophy is a key pathologic and magnetic resonance imaging (MRI) feature of human Alzheimer’s disease (AD). has not been documented via MRI in canine cognitive dysfunction (CCD), which considered as the dog model AD.Aim: The purpose this retrospective comparative volumetric study was to compare total hippocampal volumes between successfully aging (control) dogs diagnosed with CCD.Methods: Mimics® software used derive brain from studies 42 (? 9 years): 16 CCD 26 controls. were normalized volume these values compared groups using Mann–Whitney U tests.Results: Total significantly less for patients control (p = 0.04).Conclusion: results suggest that – similar AD pathological CCD. This finding potential importance both investigating mechanisms related dementia well future hippocampal-targeted therapies.